Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, Tris(1,1-Dimethylethyl) Ethyl Ester is a key protected intermediate in the synthesis of macrocyclic chelating agents. This compound is critically important for the preparation of high-purity DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its derivatives, which are essential for advanced medical imaging and therapeutic applications. It is primarily needed by manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent sectors for developing next-generation radiopharmaceuticals and contrast agents.

Application

• Synthesis of DOTA and its analogs for use as bifunctional chelators.
• Production of radiopharmaceutical precursors for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).
• Manufacturing of MRI contrast agents, particularly gadolinium-based complexes.
• Development of targeted radiotherapy agents, including those using lutetium-177, yttrium-90, or actinium-225.
• Research and development of novel macrocyclic ligands for metal ion separation and catalysis.
• Production of high-purity chemical standards for analytical and quality control laboratories.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, Tris(1,1-Dimethylethyl) Ethyl Ester
CAS No.	825625-07-8
Molecular Formula	C30H56N4O8
Molecular Weight	600.79 g/mol
Synonyms	DOTA-tris(t-butyl) ester; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid Tris(tert-butyl) Ester; DOTA-tris(tBu) ester; Tris(tert-butyl) DOTA ester; 2,2',2''-(1,4,7,10-Tetraazacyclododecane-1,4,7-triyl)triacetic acid tris(1,1-dimethylethyl) ester; Protected DOTA intermediate; Macrocyclic chelator precursor; DOTA-tris(O-t-butyl) ester
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, Tris(1,1-Dimethylethyl) Ethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical intermediate applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ICH guidelines and can provide material for GMP-based production upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.