Description

1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, 10-(2-Aminoethyl)-, Tris(1,1-Dimethylethyl) Ester is a key protected intermediate in the synthesis of advanced macrocyclic chelating agents. This compound is crucial for the development of high-performance contrast agents used in medical imaging, particularly magnetic resonance imaging (MRI). It is primarily required by pharmaceutical R&D laboratories, diagnostic imaging companies, and fine chemical manufacturers engaged in producing sophisticated metal complexes.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and DOTA-like derivatives used as bifunctional chelators.
• MRI Contrast Agent Precursor: Used in the development of gadolinium-based and other lanthanide-based contrast agents for enhanced diagnostic imaging.
• Radiopharmaceuticals: Serves as a precursor for chelators that bind radioisotopes (e.g., 68Ga, 177Lu, 90Y) for targeted radiotherapy and positron emission tomography (PET) imaging.
• Research & Development: Employed in academic and industrial research for studying metal-ligand coordination chemistry and developing new diagnostic and therapeutic agents.
• Fine Chemical Synthesis: Used in multi-step organic syntheses requiring a protected polyazamacrocycle with carboxylic acid and amine functionalities.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, 10-(2-Aminoethyl)-, Tris(1,1-Dimethylethyl) Ester
CAS No.	824984-75-0
Molecular Formula	C30H56N4O6
Molecular Weight	568.79 g/mol
Synonyms	DO3A-tris(t-butyl ester)-monoamine; 10-(2-Aminoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid tris(tert-butyl) ester; DO3A-tBu3-amine; tert-Butyl DO3A-amine; Aminoethyl-DO3A-tris(tert-butyl ester); Tris(tert-butyl) 10-(2-aminoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetate; DO3A-tris(t-Bu ester)-NH2; (2-{4,7,10-Tris[2-(tert-butoxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododec-1-yl}ethyl)amine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. The product undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (anhydrous basis)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.