Description

1-[(1R,2R)-2-[(4S)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]Cyclopropyl]-3-Buten-1-One is a high-purity chiral synthon featuring a cyclopropyl and a protected diol moiety, making it a valuable building block for complex organic synthesis. Its precise stereochemistry is critical for constructing biologically active molecules with high enantiomeric purity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Asymmetric Catalysis Research: Serves as a sophisticated substrate or ligand precursor in the development of new catalytic systems for stereoselective transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high stereochemical fidelity.
• Academic & Institutional Research: A valuable tool for synthetic organic chemists in universities and research institutes studying cyclopropane chemistry and stereoselective synthesis methodologies.

Basic Information

Product Name	1-[(1R,2R)-2-[(4S)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]Cyclopropyl]-3-Buten-1-One
CAS No.	824424-40-0
Molecular Formula	C₁₂H₁₈O₃
Molecular Weight	210.27 g/mol
Synonyms	(1R,2R)-2-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]cyclopropyl vinyl ketone; (1R,2R)-2-((4S)-2,2-Dimethyl-1,3-dioxolan-4-yl)cyclopropyl vinyl ketone; 3-Buten-1-one, 1-[(1R,2R)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclopropyl]-; Chiral Cyclopropyl Vinyl Ketone Derivative; Acetonide-Protected Diol Cyclopropane Synthon
EINECS	Contact for details

Quality Control

Our production of 1-[(1R,2R)-2-[(4S)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]Cyclopropyl]-3-Buten-1-One adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to light and oxidation, prolonged exposure to air or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.