Description

(1S,2R)-1,2,3,4-Tetramethyl-1,2-cyclobutanedicarboxylic Acid is a high-purity, stereochemically defined cyclobutane derivative. This compound serves as a valuable chiral building block and intermediate in advanced organic synthesis, offering precise structural control for complex molecule construction. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a building block in stereoselective reactions to construct complex molecular architectures with defined chirality.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Material Science Research: Investigated as a monomer or precursor for synthesizing specialized polymers with unique thermal or mechanical properties.
• Academic & Industrial R&D: Employed in chemical research for methodology development and exploring new reaction pathways involving strained ring systems.

Basic Information

Item	Details
Product Name	(1S,2R)-1,2,3,4-Tetramethyl-1,2-cyclobutanedicarboxylic Acid
CAS No.	821788-15-2
Molecular Formula	C10H16O4
Molecular Weight	200.23 g/mol
Synonyms	(1S,2R)-1,2,3,4-Tetramethylcyclobutane-1,2-dicarboxylic Acid; (1S,2R)-Tetramethyl-1,2-cyclobutanedicarboxylic Acid; 1,2,3,4-Tetramethyl-1,2-cyclobutanedicarboxylic Acid, (1S,2R)-; (1S,2R)-TMCDA; cis-1,2,3,4-Tetramethyl-1,2-cyclobutanedicarboxylic Acid (stereospecific)
EINECS	Contact for details

Quality Control

Our (1S,2R)-1,2,3,4-Tetramethyl-1,2-cyclobutanedicarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. A detailed Certificate of Analysis (COA) providing specifications for identity, assay, chiral purity, and impurities is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.