Description

5-Bromo-2-Chloro-4-Trimethylsilanyl-Pyridine is a high-value organosilicon-substituted pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic combination of halogen and silyl protecting groups, enabling precise, multi-step functionalization for complex molecule construction. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science sectors, particularly for building novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl systems.
• Protecting Group Strategy: The trimethylsilyl group acts as a versatile protecting group for the 4-position, allowing for selective deprotection and further functionalization.
• Ligand Synthesis: Utilized in the preparation of complex nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	5-Bromo-2-Chloro-4-Trimethylsilanyl-Pyridine
CAS No.	821773-95-9
Molecular Formula	C9H13BrClNSi
Molecular Weight	278.65 g/mol
Synonyms	4-Trimethylsilyl-5-bromo-2-chloropyridine; 2-Chloro-5-bromo-4-(trimethylsilyl)pyridine; 5-Bromo-2-chloro-4-(trimethylsilyl)pyridine; Pyridine, 5-bromo-2-chloro-4-(trimethylsilyl)-; 4-(Trimethylsilyl)-5-bromo-2-chloropyridine; 5-Bromo-2-chloro-4-trimethylsilylpyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloro-4-Trimethylsilanyl-Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for GMP-grade intermediates and high-purity research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.