Description

Cyclobutanol, 3-Amino-2,2,4,4-Tetramethyl-, trans- is a high-purity, stereochemically defined amino alcohol building block of significant interest in advanced organic synthesis. Its rigid, highly substituted cyclobutane ring and functional amino group make it a valuable precursor for constructing complex molecular architectures with precise spatial control. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, catalyst design, and the development of novel chiral ligands.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring constrained, three-dimensional structures.
• Chiral Ligand & Catalyst Synthesis: Used in the development of asymmetric catalysts and ligands for enantioselective transformations in fine chemical manufacturing.
• Agrochemical Research: Employed as a precursor in the design and synthesis of new-generation herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Advanced Material Monomer: Acts as a specialty monomer for creating polymers with unique thermal and mechanical properties derived from the strained cyclobutane ring.
• Chemical Biology Probe: Utilized in academic and industrial research to create molecular probes for studying enzyme mechanisms and protein interactions.
• Peptidomimetics & Conformationally Restricted Peptides: Incorporated into peptide backbones to induce specific secondary structures and improve metabolic stability.

Basic Information

Product Name	Cyclobutanol, 3-Amino-2,2,4,4-Tetramethyl-, trans-
CAS No.	802276-99-9
Molecular Formula	C9H19NO
Molecular Weight	157.25 g/mol
Synonyms	trans-3-Amino-2,2,4,4-tetramethylcyclobutanol; 2,2,4,4-Tetramethyl-3-aminocyclobutanol, trans-; 3-Amino-2,2,4,4-tetramethylcyclobutan-1-ol; (1r,3r)-3-Amino-2,2,4,4-tetramethylcyclobutanol; trans-3-Amino-TMCB; Amino-TMCB-ol; Tetramethylaminocyclobutanol
EINECS	Contact for details

Quality Control

Our Cyclobutanol, 3-Amino-2,2,4,4-Tetramethyl-, trans- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure it meets the exacting standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity (HPLC/GC), chiral excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (trans-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.