Description

2-Trimethylsilylethyl 2-Cyanoacetate is a versatile organosilicon reagent featuring a protected cyanoacetate functionality. This compound is valued for its role as a key synthetic building block in advanced organic synthesis, particularly for the introduction of the cyanoacetate group under mild conditions. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediates: Serves as a crucial synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing cyano, carboxylic acid, or heterocyclic moieties.
• Agrochemical Synthesis: Employed in the production of advanced herbicides, fungicides, and insecticides where the cyanoacetate group is integral to biological activity.
• Peptide Mimetics & Modified Nucleosides: Used in the preparation of peptide analogs and modified nucleic acid derivatives for drug discovery and biochemical research.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers, coatings, and functional materials.
• Organic Synthesis Reagent: Functions as a protected form of cyanoacetic acid for Knoevenagel condensations, Michael additions, and other C-C bond-forming reactions.
• Dye & Pigment Manufacturing: Utilized in the synthesis of specialized dyes and organic pigments.

Basic Information

Product Name	2-Trimethylsilylethyl 2-Cyanoacetate
CAS No.	89634-33-3
Molecular Formula	C9H17NO2Si
Molecular Weight	199.32 g/mol
Synonyms	2-Cyanoacetic Acid 2-(Trimethylsilyl)ethyl Ester; (2-Trimethylsilyl)ethyl Cyanoacetate; 2-(Trimethylsilyl)ethyl Cyanoacetate; TMSE Cyanoacetate; Cyanoacetic Acid Trimethylsilylethyl Ester; β-Trimethylsilylethyl Cyanoacetate; NSC 334090
EINECS	Contact for details

Quality Control

Our 2-Trimethylsilylethyl 2-Cyanoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.