Description

1-Phenyl-3-(Trimethylsilyl)-2-Propyn-1-ol is a versatile organosilicon building block featuring both a phenyl and a terminal alkyne group protected by a trimethylsilyl (TMS) moiety. This compound is highly valued in advanced organic synthesis for its role as a key intermediate in the construction of complex molecular architectures, particularly in pharmaceutical and materials science research. Its unique structure makes it essential for chemists in R&D and process development who require reliable, high-purity intermediates for cross-coupling reactions and the synthesis of bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring alkyne functionalization.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the protected alkyne group enables specific structural modifications.
• Material Science Research: Serves as a monomer or precursor in the development of advanced polymers, dendrimers, and functional organic materials.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Glaser, and other palladium-catalyzed coupling reactions to form conjugated systems.
• Organic Synthesis Reagent: Employed in academic and industrial laboratories for the preparation of complex natural products and novel chemical entities.
• Ligand and Catalyst Development: Used as a precursor for synthesizing specialized ligands for metal catalysis and organometallic chemistry.

Basic Information

Product Name	1-Phenyl-3-(Trimethylsilyl)-2-Propyn-1-ol
CAS No.	89530-34-7
Molecular Formula	C12H16OSi
Molecular Weight	204.34 g/mol
Synonyms	1-Phenyl-3-(trimethylsilyl)prop-2-yn-1-ol; 3-Trimethylsilyl-1-phenyl-2-propyn-1-ol; (1-Hydroxy-1-phenyl-2-propynyl)trimethylsilane; TMS-Protected Phenyl Propargyl Alcohol; α-(Trimethylsilylethynyl)benzyl Alcohol; 89530-34-7; 1-Phenyl-3-(trimethylsilyl)-2-propyn-1-& CAS NO 89530-34-7
EINECS	Contact for details

Quality Control

Our 1-Phenyl-3-(Trimethylsilyl)-2-Propyn-1-ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.