Description

4-(Trifluoromethyl)Benzenesulfinic Acid Sodium Salt is a versatile organosulfur compound featuring a reactive sulfinate group and a trifluoromethyl substituent. This combination makes it a valuable building block in synthetic organic chemistry, particularly for the introduction of the (trifluoromethyl)phenyl moiety. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecules, as well as in materials science for creating specialty polymers and ligands.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring the bioisosteric trifluoromethyl group to modulate potency, metabolic stability, and lipophilicity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental persistence.
• Ligand & Catalyst Preparation: Serves as a precursor for sulfoxide and sulfonamide ligands used in asymmetric catalysis and transition metal complexes.
• Polymer & Material Science: Incorporated into specialty polymers to impart unique surface properties, chemical resistance, or to act as a reactive site for further functionalization.
• Cross-Coupling Reactions: Employed in palladium-catalyzed cross-coupling reactions (e.g., with aryl halides) to form biaryl structures, a common motif in many functional materials.
• Organic Synthesis Reagent: Acts as a nucleophilic sulfinating agent for the preparation of sulfones, sulfoxides, and other sulfur-containing compounds in research settings.

Basic Information

Product Name	4-(Trifluoromethyl)Benzenesulfinic Acid Sodium Salt
CAS No.	89520-63-8
Molecular Formula	C7H4F3NaO2S
Molecular Weight	232.16 g/mol
Synonyms	Sodium 4-(Trifluoromethyl)benzenesulfinate; Sodium α,α,α-Trifluoro-p-toluenesulfinate; p-(Trifluoromethyl)benzenesulfinic Acid Sodium Salt; 4-(Trifluoromethyl)phenylsulfinic Acid Sodium Salt; Sodium (4-Trifluoromethylphenyl)sulfinate; Benzenesulfinic acid, 4-(trifluoromethyl)-, sodium salt (1:1)
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Benzenesulfinic Acid Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to minimize exposure to air and moisture upon opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.