Description

1-Boc-4-[2-(Toluene-4-Sulfonyloxy)-Ethyl]-Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine core with a tosylate leaving group. This compound is critically important for its role in facilitating efficient and selective chemical transformations, particularly in the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), especially within medicinal chemistry programs targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly those containing functionalized piperidine scaffolds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Alkaloid Synthesis: Serves as a precursor in the laboratory-scale synthesis of complex natural products and alkaloid derivatives.
• Peptidomimetic Development: Employed in the construction of peptidomimetics and other bioactive compounds designed to modulate protein-protein interactions.
• Chemical Biology Probes: Utilized for creating specialized molecular probes to study enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	1-Boc-4-[2-(Toluene-4-Sulfonyloxy)-Ethyl]-Piperidine
CAS No.	89151-45-1
Molecular Formula	C19H29NO5S
Molecular Weight	383.50 g/mol
Synonyms	1-Boc-4-(2-((4-Methylphenyl)sulfonyloxy)ethyl)piperidine; tert-Butyl 4-[2-[(4-methylphenyl)sulfonyloxy]ethyl]piperidine-1-carboxylate; 4-(2-((p-Tolylsulfonyl)oxy)ethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[2-(p-toluenesulfonyloxy)ethyl]piperidine; N-Boc-4-(2-(tosyloxy)ethyl)piperidine; 4-(2-Tosyloxyethyl)piperidine-1-carboxylic acid tert-butyl ester; BOC-Piperidine-4-ethyl tosylate derivative
EINECS	Contact for details

Quality Control

Our 1-Boc-4-[2-(Toluene-4-Sulfonyloxy)-Ethyl]-Piperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.