Description

1-(T-Butyldimethylsiloxy)-3-Chloropropane is a versatile organosilicon reagent featuring both a protected hydroxyl group and a reactive chloroalkyl chain. This bifunctional nature makes it a critical intermediate for the controlled synthesis of complex molecules, particularly in pharmaceutical and fine chemical manufacturing. It is essential for researchers and process chemists in the life sciences, agrochemical, and advanced materials sectors who require high-purity building blocks for constructing specific molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing functionalized propyl linkers.
• Peptide & Nucleotide Chemistry: Used in solid-phase synthesis and the preparation of modified biomolecules where a protected, tethering arm is required.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) group protects alcohol functionalities during multi-step synthetic sequences.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and polymerization.
• Material Science: Employed in the surface modification of silica and other materials, or as a monomer for specialty polymers.
• Agrochemical Synthesis: An intermediate in the production of certain herbicides, fungicides, and plant growth regulators.

Basic Information

Item	Detail
Product Name	1-(T-Butyldimethylsiloxy)-3-Chloropropane
CAS No.	89031-82-3
Molecular Formula	C9H21ClOSi
Molecular Weight	208.80 g/mol
Synonyms	3-Chloro-1-[(1,1-dimethylethyl)dimethylsilyl]oxy]propane; 3-Chloropropyl tert-butyldimethylsilyl ether; 1-Chloro-3-((tert-butyldimethylsilyl)oxy)propane; TBDMS-3-Chloropropyl Ether; (3-Chloropropoxy)(tert-butyl)dimethylsilane; tert-Butyl(3-chloropropoxy)dimethylsilane; 89031-82-3; 1-(tert-Butyldimethylsiloxy)-3-chloropropane
EINECS	Contact for details

Quality Control

Our 1-(T-Butyldimethylsiloxy)-3-Chloropropane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.