Description

1-Naphthalenesulfonic Acid, 5-(2-((2,5-Dioxo-1-Pyrrolidinyl)Oxy)-2-Oxo Ethoxy)- is a specialized naphthalene derivative functionalized with a reactive N-hydroxysuccinimide (NHS) ester group. This compound is a critical intermediate for bioconjugation and crosslinking chemistry, enabling the stable attachment of molecules to surfaces or other biomolecules under mild aqueous conditions. It is primarily utilized by researchers and manufacturers in the life sciences, diagnostics, and advanced materials sectors for developing assays, probes, and functionalized polymers.

Application

• Bioconjugation Reagent: Used to covalently link amines on proteins, peptides, or antibodies to other molecules or solid supports for diagnostic kits and biosensors.
• Polymer Functionalization: Serves as a key monomer or crosslinker for synthesizing specialty polymers with sulfonic acid and reactive ester groups for ion-exchange or affinity materials.
• Surface Modification: Employed to create reactive NHS-activated surfaces on chips, beads, or membranes for microarray and solid-phase assay development.
• Chemical Synthesis Intermediate: Acts as a building block in organic synthesis for creating more complex naphthalene-based dyes, ligands, or pharmaceutical intermediates.
• Material Science Research: Used in R&D for developing novel functional materials, hydrogels, and coatings with specific chemical reactivity.

Basic Information

Product Name	1-Naphthalenesulfonic Acid, 5-(2-((2,5-Dioxo-1-Pyrrolidinyl)Oxy)-2-Oxo Ethoxy)-
CAS No.	88924-72-5
Molecular Formula	C₁₈H₁₅NO₉S
Molecular Weight	421.38 g/mol
Synonyms	5-(2-((2,5-Dioxo-1-pyrrolidinyl)oxy)-2-oxoethoxy)-1-naphthalenesulfonic acid; NHS-activated naphthalenesulfonic acid; 1-Naphthalenesulfonic acid, 5-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethoxy]-; Naphthalene-1-sulfonic acid NHS ester derivative; Succinimidyl ester of 5-carboxy-1-naphthalenesulfonic acid; Reactive naphthalene sulfonate ester; Bioconjugation linker 88924-72-5
EINECS	Contact for details

Quality Control

Our 1-Naphthalenesulfonic Acid, 5-(2-((2,5-Dioxo-1-Pyrrolidinyl)Oxy)-2-Oxo Ethoxy)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant to maintain stability and prevent hydrolysis of the reactive ester group.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.