Description

4-Hydroxybicyclo[2.2.1]heptane-1-carboxylic acid is a functionalized bicyclic carboxylic acid derivative, serving as a versatile chiral building block in advanced organic synthesis. Its rigid, polycyclic framework and multiple functional groups make it a valuable intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is particularly relevant for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Used in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Material Science Research: Monomer or precursor for specialty polymers and advanced materials requiring rigid, functionalized components.
• Flavor and Fragrance Industry: Intermediate for the synthesis of complex, high-value aroma chemicals and flavorants.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and total synthesis projects.

Basic Information

Product Name	4-Hydroxybicyclo[2.2.1]heptane-1-Carboxylic Acid
CAS No.	88888-30-6
Molecular Formula	C8H12O3
Molecular Weight	156.18 g/mol
Synonyms	4-Hydroxynorbornane-1-carboxylic Acid; 1-Carboxy-4-hydroxynorbornane; Bicyclo[2.2.1]heptane-1-carboxylic acid, 4-hydroxy-; 4-Hydroxy-1-norbornanecarboxylic Acid; 1-Norbornanecarboxylic acid, 4-hydroxy-; Endo-4-Hydroxybicyclo[2.2.1]heptane-1-carboxylic Acid (stereoisomer); Exo-4-Hydroxybicyclo[2.2.1]heptane-1-carboxylic Acid (stereoisomer)
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxybicyclo[2.2.1]heptane-1-carboxylic acid adheres to a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure identity, strength, purity, and composition. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support custom synthesis and can tailor specifications to meet specific GMP, ISO, or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is compatible with strong acids and organic solvents but should be kept separate from strong bases and oxidizing agents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (specify isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.