Description

1-[(4-Nitrophenyl)Sulfonyl]Pyrrolidine-2-Carboxylic Acid is a high-purity, specialized organic building block featuring a pyrrolidine carboxylic acid core functionalized with a 4-nitrophenylsulfonyl group. This compound is valued for its role as a key intermediate in advanced synthetic chemistry, particularly in the development of novel pharmaceuticals and bioactive molecules. It is essential for research and production in medicinal chemistry, where it serves as a precursor for protease inhibitors and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting proteases and other enzymes.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new bioactive compounds.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for creating peptide-like molecules with enhanced stability and bioavailability.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzyme function and mechanism.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom chemical synthesis services catering to the life sciences industry.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental research in organic synthesis and drug discovery.

Basic Information

Product Name	1-[(4-Nitrophenyl)Sulfonyl]Pyrrolidine-2-Carboxylic Acid
CAS No.	88867-96-3
Molecular Formula	C11H12N2O6S
Molecular Weight	300.29 g/mol
Synonyms	2-Pyrrolidinecarboxylic acid, 1-[(4-nitrophenyl)sulfonyl]-; 1-(4-Nitrobenzenesulfonyl)pyrrolidine-2-carboxylic acid; N-(4-Nitrobenzenesulfonyl)proline; (S)-1-(4-Nitrobenzenesulfonyl)pyrrolidine-2-carboxylic acid; 1-(4-Nitrophenylsulfonyl)-L-proline; NSC 405122; Proline derivative, N-tosyl-4-nitro; L-Proline, N-[(4-nitrophenyl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our 1-[(4-Nitrophenyl)Sulfonyl]Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.