Description

Ethyl (R)-4-Phenyl-2-[[(Trifluoromethyl)Sulfonyl]Oxy]Butyrate is a high-value chiral building block and triflate ester derivative, critical for advanced organic synthesis. Its primary commercial value lies in its role as a versatile electrophilic intermediate for palladium-catalyzed cross-coupling reactions, enabling the efficient construction of complex molecules. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, where it is used to introduce chiral centers and aryl groups into target active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of chiral drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Cross-Coupling Reactions: Serves as an electrophile in Suzuki-Miyaura, Negishi, and Stille couplings to form carbon-carbon bonds.
• Asymmetric Synthesis: Utilized in the construction of enantiomerically pure compounds due to its defined (R)-configuration.
• Agrochemical Research: Building block for developing novel, chiral active ingredients with enhanced efficacy and selectivity.
• Material Science: Potential monomer or intermediate for specialty polymers and advanced organic materials.
• Process Chemistry Development: Used in route scouting and optimization for scalable manufacturing of complex organic molecules.

Basic Information

Product Name	Ethyl (R)-4-Phenyl-2-[[(Trifluoromethyl)Sulfonyl]Oxy]Butyrate
CAS No.	88767-98-0
Molecular Formula	C₁₃H₁₅F₃O₅S
Molecular Weight	340.32 g/mol
Synonyms	(R)-Ethyl 4-Phenyl-2-(((trifluoromethyl)sulfonyl)oxy)butanoate; (R)-Ethyl 2-(Trifluoromethanesulfonyloxy)-4-phenylbutyrate; Ethyl (R)-2-[(Trifluoromethyl)sulfonyloxy]-4-phenylbutanoate; (R)-4-Phenyl-2-((trifluoromethyl)sulfonyl)oxybutyric Acid Ethyl Ester; (R)-Ethyl 4-Phenyl-2-((trifluoromethanesulfonyl)oxy)butyrate; (R)-2-OTf-4-Phenylbutyric Acid Ethyl Ester; (R)-α-Triflyloxy-4-phenylbutyric Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl (R)-4-Phenyl-2-[[(Trifluoromethyl)Sulfonyl]Oxy]Butyrate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) are provided, detailing specifications for identity, assay, chiral purity, and impurity profiles. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.