Description

(S)-2-(1,3-Dioxoisoindolin-2-Yl)Propyl 4-Methylbenzenesulfonate is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in its role as a key precursor for the synthesis of enantiomerically pure compounds, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in asymmetric synthesis and advanced drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions to introduce the (S)-configured propyl tosylate moiety into target molecules.
• Peptidomimetic Research: Serves as a protected amino acid derivative for constructing peptide analogs and peptidomimetics in medicinal chemistry.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for catalytic asymmetric transformations.
• Chemical Biology Probes: Utilized in the synthesis of labeled or modified biomolecules for studying biological mechanisms and interactions.
• Academic and R&D Laboratories: A valuable reagent for methodological development in organic synthesis and for exploring new synthetic pathways.

Basic Information

Product Name	(S)-2-(1,3-Dioxoisoindolin-2-Yl)Propyl 4-Methylbenzenesulfonate
CAS No.	88722-24-1
Molecular Formula	C18H17NO5S
Molecular Weight	359.40 g/mol
Synonyms	(S)-2-(1,3-Dioxoisoindolin-2-yl)propyl p-toluenesulfonate; (S)-N-(1-Tosyloxypropan-2-yl)phthalimide; (S)-2-Phthalimidopropyl Tosylate; (S)-2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl 4-methylbenzenesulfonate; L-2-Phthalimidopropyl p-Toluenesulfonate; (S)-1-Tosyloxy-2-phthalimidopropane; (S)-2-(1,3-Dioxoisoindolin-2-yl)-1-propyl 4-methylbenzenesulfonate
EINECS	Contact for details

Quality Control

Our (S)-2-(1,3-Dioxoisoindolin-2-Yl)Propyl 4-Methylbenzenesulfonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including chiral purity verification, to meet the stringent requirements of pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.