Description

(1S)-3,4,5,10-Tetrahydro-9-Hydroxy-1α-Methyl-5,10-Dioxo-4Aβ,10Aβ-Epoxy-1H-Naphtho[2,3-C]Pyran-3β-Acetic Acid Methyl Ester is a high-purity, structurally complex organic compound with significant synthetic utility. This chemical serves as a critical advanced intermediate in the synthesis of complex pharmaceutical molecules, offering a precise stereochemical framework. It is primarily sought after by research institutions and pharmaceutical development companies engaged in the creation of novel therapeutic agents, particularly in the fields of oncology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex, biologically active compounds and active pharmaceutical ingredients (APIs).
• Organic Synthesis Research: Used in academic and industrial R&D for developing new synthetic methodologies and exploring structure-activity relationships.
• Precursor for Anticancer Agents: Serves as a scaffold in the development of novel chemotherapeutic and targeted cancer therapies.
• Anti-inflammatory Drug Development: Utilized in the synthesis pathway for potential anti-inflammatory and immunomodulatory drugs.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of specialty pharmaceuticals.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	(1S)-3,4,5,10-Tetrahydro-9-Hydroxy-1α-Methyl-5,10-Dioxo-4Aβ,10Aβ-Epoxy-1H-Naphtho[2,3-C]Pyran-3β-Acetic Acid Methyl Ester
CAS No.	88293-10-1
Molecular Formula	C₁₉H₁₈O₇
Molecular Weight	358.34 g/mol
Synonyms	Methyl (1S,3S,4R,4aR,10aR)-9-Hydroxy-1-methyl-5,10-dioxo-1,3,4,4a,10,10a-hexahydro-4,10a-epoxynaphtho[2,3-c]pyran-3-acetate; 9-Hydroxy-1α-methyl-5,10-dioxo-4aβ,10aβ-epoxy-1,3,4,4a,10,10a-hexahydro-1H-naphtho[2,3-c]pyran-3β-acetic acid methyl ester; (1S,3S,4R,4aR,10aR)-Methyl 9-hydroxy-1-methyl-5,10-dioxo-1,3,4,4a,10,10a-hexahydro-4,10a-epoxynaphtho[2,3-c]pyran-3-acetate; 88293-10-1; Methyl ester of the corresponding naphthopyran acetic acid derivative.
EINECS	Contact for details

Quality Control

Our (1S)-3,4,5,10-Tetrahydro-9-Hydroxy-1α-Methyl-5,10-Dioxo-4Aβ,10Aβ-Epoxy-1H-Naphtho[2,3-C]Pyran-3β-Acetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.