Description

1H-Naphtho[2,3-C]Pyran-3-Acetic Acid, 3,4,5,10-Tetrahydro-9-Hydroxy-1-Methyl-5,10-Dioxo-(1S,3R)- is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. Its complex fused-ring structure and specific stereochemistry make it a valuable building block for the development of novel pharmacologically active compounds. This product is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly those working on new chemical entities with specific three-dimensional architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular scaffolds.
• Organic Synthesis Building Block: Used in advanced multi-step synthesis to construct complex polycyclic frameworks found in natural products and specialty chemicals.
• Asymmetric Catalysis Research: Serves as a substrate or a precursor for ligands in the study and development of new asymmetric catalytic reactions.
• Material Science Research: Potential precursor for the synthesis of organic semiconductors or advanced functional materials due to its conjugated system.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	1H-Naphtho[2,3-C]Pyran-3-Acetic Acid, 3,4,5,10-Tetrahydro-9-Hydroxy-1-Methyl-5,10-Dioxo-(1S,3R)-
CAS No.	88293-09-8
Molecular Formula	C₁₆H₁₄O₆
Molecular Weight	302.28 g/mol
Synonyms	(1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid; (1S,3R)-9-Hydroxy-1-methyl-5,10-dioxo-3,4,5,10-tetrahydro-1H-naphtho[2,3-c]pyran-3-acetic acid; 1H-Naphtho[2,3-c]pyran-3-acetic acid, 3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-, (1S,3R)-; (S,R)-Tetrahydrohydroxymethyldioxonaphthopyranacetic acid; NSC 339586; A chiral naphthopyran acetic acid derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from chiral HPLC, NMR, and other relevant analytical methods to confirm compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (for specified enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.