Description

Bromoenol Lactone (BEL) is a potent and selective mechanism-based inhibitor of calcium-independent phospholipase A2 (iPLA2). This compound matters for researchers and pharmaceutical developers because it serves as a critical biochemical tool for elucidating the role of iPLA2 in various cellular signaling pathways and disease states. It is primarily needed by the life sciences sector for applications in biochemical research, drug discovery, and the study of inflammatory and neurodegenerative processes.

Application

• Biochemical research tool for studying calcium-independent phospholipase A2 (iPLA2) activity and inhibition.
• Investigation of cellular signaling pathways involving lipid mediators, such as arachidonic acid release.
• Research into the role of iPLA2 in apoptosis (programmed cell death) and related cellular mechanisms.
• Studies of inflammatory processes where iPLA2 is implicated.
• Neurobiological research exploring iPLA2 function in neurological disorders.
• Target validation and hit-to-lead optimization in pharmaceutical discovery programs focused on iPLA2.

Basic Information

Product Name	Bromoenol Lactone
CAS No.	88070-98-8
Molecular Formula	C11H15BrO3
Molecular Weight	275.14 g/mol
Synonyms	BEL; (E)-6-(Bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one; (E)-6-(Bromomethylene)-3-(1-naphthyl)-3,4,5,6-tetrahydro-2H-pyran-2-one; Bromoenol Lactone Inhibitor; iPLA2 Inhibitor VI; Calcium-Independent Phospholipase A2 Inhibitor; 6-(Bromomethylene)-3-(1-naphthalenyl)-tetrahydro-2H-pyran-2-one
EINECS	Contact for details

Quality Control

Our Bromoenol Lactone CAS NO 88070-98-8 is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.