Description

(S)-((2-Guanidino-4-Thiazolyl)Methylisothiourea Dihydrochloride is a high-purity, non-racemic chiral building block and pharmaceutical intermediate of significant synthetic value. This compound matters for its role in the development of novel bioactive molecules, particularly in medicinal chemistry research targeting specific enzyme inhibition. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of advanced therapeutic candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly in areas requiring guanidine or thiazole pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and as a building block for creating focused libraries for high-throughput screening.
• Biochemical Tool Compound: Potential use in studying biological pathways involving arginine mimicry or nitric oxide synthase (NOS) due to its guanidino group.
• Asymmetric Synthesis: Serves as a chiral precursor for the synthesis of more complex, enantiomerically pure molecules in fine chemical production.
• Reference Standard: Suitable for use as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	(S)-((2-Guanidino-4-Thiazolyl)Methylisothiourea Dihydrochloride
CAS No.	88046-01-9
Molecular Formula	C6H12Cl2N6S2
Molecular Weight	303.23 g/mol
Synonyms	(S)-2-[(2-Guanidino-1,3-thiazol-4-yl)methyl]isothiourea Dihydrochloride; (S)-2-[(2-Aminoiminomethylamino-4-thiazolyl)methyl]isothiourea Dihydrochloride; (S)-AMTGA Dihydrochloride; L-2-[(2-Guanidino-4-thiazolyl)methyl]isothiourea Dihydrochloride; (S)-Guanidinothiazolemethylisothiourea Dihydrochloride; S-GMTI Dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-((2-Guanidino-4-Thiazolyl)Methylisothiourea Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.