Description

3-Iodobenzyl-Guanidine Hemisulfate is a high-purity chemical building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical precursor in the synthesis of radiopharmaceuticals and targeted molecular probes, particularly for diagnostic imaging applications. It is essential for researchers and manufacturers in the radiochemistry, oncology, and nuclear medicine sectors who require reliable, high-quality intermediates for developing novel diagnostic agents.

Application

• Radiopharmaceutical Precursor: Key intermediate in the synthesis of meta-iodobenzylguanidine (MIBG) analogs used in diagnostic nuclear medicine.
• Molecular Imaging Probe Development: Serves as a building block for creating targeted agents for SPECT (Single-Photon Emission Computed Tomography) imaging.
• Oncology Research: Used in the development of compounds for the diagnosis and staging of neuroendocrine tumors (e.g., pheochromocytoma, neuroblastoma).
• Bioconjugation Chemistry: Employed in the modification of peptides, antibodies, or other biomolecules with iodine for labeling purposes.
• Reference Standard: Acts as a non-radioactive reference standard in analytical method development and quality control for radioactive drug products.
• Academic & Contract Research: Utilized in university and CRO laboratories for investigating adrenergic uptake mechanisms and developing new diagnostic methodologies.

Basic Information

Product Name	3-Iodobenzyl-Guanidine Hemisulfate
CAS No.	87862-25-7
Molecular Formula	C8H10IN3 • ½H2SO4
Molecular Weight	324.10 g/mol (free base) / 381.15 g/mol (hemisulfate salt)
Synonyms	m-Iodobenzylguanidine Hemisulfate; 3-Iodo-benzylguanidine Hemisulfate; 1-(3-Iodobenzyl)guanidine Hemisulfate; MIBG Precursor Hemisulfate; Guanidine, N-(3-iodobenzyl)-, hemisulfate; 87862-25-7; meta-Iodobenzylguanidine Hemisulfate Salt
EINECS	Contact for details

Quality Control

Our 3-Iodobenzyl-Guanidine Hemisulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request. We support compliance with relevant guidelines for pharmaceutical starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.