Description

1-[4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]-2,2,2-Trifluoro-Ethanone Oxime is a specialized organosilicon-protected oxime derivative, a key synthetic intermediate in advanced organic synthesis. Its value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which offers superior stability for sensitive functional group manipulation under a wide range of reaction conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of complex molecules, particularly those containing trifluoromethyl and oxime functional groups in drug discovery and development.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Advanced Material Precursor: Serves as a monomer or intermediate in the synthesis of specialty polymers and functional materials with tailored properties.
• Organic Synthesis Reagent: Employed in multi-step synthetic routes for the protected introduction of carbonyl equivalents and the construction of complex molecular architectures.
• Chemical Research & Development: A valuable tool for academic and industrial R&D chemists exploring new reaction methodologies and compound libraries.

Basic Information

Product Name	1-[4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]-2,2,2-Trifluoro-Ethanone Oxime
CAS No.	87736-77-4
Molecular Formula	C16H24F3NO2Si
Molecular Weight	347.46 g/mol
Synonyms	4-[(tert-Butyldimethylsilyloxy)methyl]benzaldehyde O-(2,2,2-trifluoroethyl) oxime; 2,2,2-Trifluoro-1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]phenyl]ethanone oxime; TBDMS-protected Trifluoroacetophenone Oxime; 1-[4-[[(tert-Butyldimethylsilyloxy)methyl]phenyl]-2,2,2-trifluoroethanone oxime; (4-((tert-Butyldimethylsilyloxy)methyl)phenyl)(trifluoromethyl)ketoxime
EINECS	Contact for details

Quality Control

Our production of 1-[4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]-2,2,2-Trifluoro-Ethanone Oxime adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity, purity, and the absence of critical impurities. We provide full traceability and detailed Certificates of Analysis (COA) upon request, ensuring compliance with your specific R&D or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation. Recommended storage temperature: 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.