Description

Tetrahydro-2H-Pyran-2,3-Diol is a versatile chiral diol derivative of tetrahydropyran, serving as a valuable building block in advanced organic synthesis. This compound is particularly significant for its role as a key intermediate in the production of pharmaceuticals, agrochemicals, and fine chemicals, where its stereochemistry and functional groups enable precise molecular construction. It is essential for research institutions and industrial manufacturers engaged in developing active pharmaceutical ingredients (APIs), complex natural product analogs, and specialty polymers.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of antiviral, anticancer, and central nervous system (CNS) active drug candidates.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and plant growth regulators with enhanced efficacy and selectivity.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and high-value specialty chemicals requiring specific stereochemical configurations.
• Polymer Chemistry: Acts as a monomer or chain modifier for producing specialized polyesters and polyethers with tailored properties.
• Asymmetric Catalysis: Employed as a ligand or auxiliary in catalytic systems to induce chirality in synthetic reactions.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	Tetrahydro-2H-Pyran-2,3-Diol
CAS No.	86728-74-7
Molecular Formula	C5H10O3
Molecular Weight	118.13 g/mol
Synonyms	2,3-Dihydroxytetrahydropyran; (2R,3S)-2,3-Dihydroxytetrahydropyran; Tetrahydro-2H-pyran-2,3-diol; 2,3-Dihydroxy-3,4,5,6-tetrahydro-2H-pyran; THP-diol; Pyran-2,3-diol, tetrahydro-; 2,3-Dihydroxytetrahydro-2H-pyran
EINECS	Contact for details

Quality Control

Our Tetrahydro-2H-Pyran-2,3-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with cGMP, ISO, and REACH regulations as required for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.