Description

4A-Hydroxyavermectin B1 is a key hydroxylated derivative of the potent macrocyclic lactone, avermectin B1. This compound is of significant interest for its role as a crucial intermediate in the synthesis of advanced agrochemicals and pharmaceuticals, offering a strategic building block for chemical modification. It is primarily utilized by research institutions and manufacturers in the agrochemical and pharmaceutical sectors for developing novel active ingredients and conducting structure-activity relationship studies.

Application

• Agrochemical Intermediate: A vital precursor in the research and synthesis of next-generation acaricides, insecticides, and nematicides.
• Pharmaceutical Research: Serves as a key intermediate for developing novel antiparasitic and antimicrobial agents in medicinal chemistry.
• Biochemical Studies: Used in academic and industrial laboratories to study the mode of action and metabolism of avermectin-class compounds.
• Veterinary Product Development: Employed in the R&D of new formulations for animal health applications targeting parasites.
• Reference Standard: Functions as an analytical standard for quality control and regulatory testing of related agrochemical products.

Basic Information

Product Name	4A-Hydroxyavermectin B1
CAS No.	86629-72-3
Molecular Formula	C48H72O15
Molecular Weight	889.1 g/mol
Synonyms	4α-Hydroxyavermectin B1; 4-Deoxy-4α-hydroxy-avermectin B1; 4α-Hydroxyabamectin; 4α-OH-Avermectin B1; 4-Deoxy-4α-hydroxy-22,23-dihydroavermectin B1a/1b mixture; 4α-Hydroxy MK-243; Avermectin B1, 4α-hydroxy-
EINECS	Contact for details

Quality Control

Our 4A-Hydroxyavermectin B1 is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets precise specifications for research and synthesis purposes. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.