Description

4-Bromo-α-(Trimethylsilyl)Toluene is a valuable organosilicon intermediate featuring both a reactive bromine atom and a robust trimethylsilyl protecting group. This compound is essential for advanced synthetic chemistry, enabling precise carbon-carbon bond formation and serving as a versatile building block for complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in cross-coupling reactions like Suzuki-Miyaura and Negishi couplings.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection agents, leveraging its halogen and silicon functionalities.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of silicon-containing polymers, liquid crystals, and other functional organic materials.
• Organic Synthesis Building Block: Facilitates the introduction of benzyl and silyl groups in multi-step synthetic sequences for complex natural products and fine chemicals.

Basic Information

Product Name	4-Bromo-α-(Trimethylsilyl)Toluene
CAS No.	86605-93-8
Molecular Formula	C10H15BrSi
Molecular Weight	243.22 g/mol
Synonyms	1-Bromo-4-[(trimethylsilyl)methyl]benzene; p-Bromo(trimethylsilylmethyl)benzene; (4-Bromobenzyl)trimethylsilane; α-Trimethylsilyl-4-bromotoluene; 4-Bromobenzyltrimethylsilane; TMS-Protected 4-Bromobenzyl Bromide Equivalent; 86605-93-8
EINECS	Contact for details

Quality Control

Our 4-Bromo-α-(Trimethylsilyl)Toluene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.