Description

Tos-Peg5-Thp CAS NO 86259-89-4 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a tosylate (Tos) leaving group and a tetrahydropyranyl (THP) protected hydroxyl group, separated by a pentaethylene glycol (PEG5) spacer. This compound serves as a critical building block in the synthesis of complex bioconjugates and advanced drug delivery systems, enabling precise and controlled chemical linkages. It is essential for researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors who require reliable, high-quality intermediates for developing novel therapeutics and diagnostic agents.

Application

• Pharmaceutical Linker Chemistry: Acts as a versatile heterobifunctional crosslinker for conjugating drugs, peptides, or targeting ligands to antibodies, proteins, or nanoparticles.
• PEGylation Reagent: Used to introduce PEG chains onto bioactive molecules to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Prodrug Synthesis: Employed in the design of prodrugs where the THP-protected group allows for controlled release of the active pharmaceutical ingredient (API) under specific physiological conditions.
• Polymer & Dendrimer Construction: Serves as a key monomer or branching unit in the stepwise synthesis of functionalized polymers and dendrimers for biomedical applications.
• Surface Functionalization: Used to modify surfaces (e.g., gold nanoparticles, silica, medical devices) with reactive PEG layers for creating non-fouling or specifically reactive interfaces.
• Solid-Phase Peptide Synthesis (SPPS): Incorporated as a handle or spacer in peptide synthesis to improve coupling efficiency and solubility.
• Diagnostic Probe Development: Facilitates the attachment of fluorophores, chelators, or other reporter molecules to biomolecules for imaging and diagnostic assays.
• Bioconjugation Research: A fundamental tool in academic and industrial R&D for exploring new bioconjugation strategies and creating novel biomolecular architectures.

Basic Information

Product Name	Tos-Peg5-Thp
CAS No.	86259-89-4
Molecular Formula	C28H48O11S
Molecular Weight	592.75 g/mol
Synonyms	2,5,8,11,14-Pentaoxaheptadecan-17-yl 4-methylbenzenesulfonate, 2-(Tetrahydro-2H-pyran-2-yloxy)ethyl ether; Tetraethylene glycol monotosylate THP ether; THP-PEG5-OTs; PEG5 Tosylate THP Ether; Heterobifunctional PEG derivative Tos-PEG5-THP; p-Toluenesulfonic acid 2,5,8,11,14-pentaoxaheptadecan-17-yl ester, 2-(tetrahydro-2H-pyran-2-yloxy)ethyl ether; Tosyl-Pentaethylene glycol-THP ether
EINECS	Contact for details

Quality Control

Our Tos-Peg5-Thp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable consistency and traceability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (e.g., argon or nitrogen) in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.