Description

α-Naphthoflavone-7,8-Dihydrodiol is a specific, high-purity dihydrodiol metabolite of the synthetic flavonoid, α-naphthoflavone. This compound is of significant value in biochemical and pharmacological research, particularly for studying cytochrome P450 (CYP) enzyme metabolism and the formation of reactive intermediates. It is primarily required by research institutions, pharmaceutical development laboratories, and chemical manufacturers focused on drug metabolism studies, toxicology research, and as a critical reference standard for analytical method development.

Application

• Biochemical Research: Used as a key metabolite in studies investigating the metabolic pathways and bioactivation of polycyclic aromatic hydrocarbons (PAHs) and synthetic flavonoids.
• Enzyme Activity Studies: Serves as a specific substrate or product for characterizing the activity and inhibition of cytochrome P450 enzymes, particularly CYP1A1 and CYP1A2.
• Analytical Reference Standard: Employed as a high-purity certified reference material (CRM) for the calibration of HPLC, LC-MS, and GC-MS systems in analytical laboratories.
• Toxicology & Mutagenicity Assays: Utilized in in vitro and in vivo studies to understand the genotoxic potential and metabolic activation of parent compounds.
• Pharmaceutical Development: Acts as a critical intermediate or metabolite standard in the ADME (Absorption, Distribution, Metabolism, Excretion) profiling of new chemical entities.
• Academic Research: Fundamental tool for university and institutional research into chemical carcinogenesis and detoxification mechanisms.

Basic Information

Product Name	α-Naphthoflavone-7,8-Dihydrodiol
CAS No.	86126-12-7
Molecular Formula	C19H14O4
Molecular Weight	306.31 g/mol
Synonyms	7,8-Dihydro-7,8-dihydroxy-α-naphthoflavone; α-NF-7,8-diol; ANF-7,8-dihydrodiol; 7,8-Dihydroxy-7,8-dihydro-α-naphthoflavone; Benzo[h]chromen-4-one, 7,8-dihydro-7,8-dihydroxy-2-(1-naphthalenyl)-; 2-(Naphthalen-1-yl)-7,8-dihydroxy-7,8-dihydro-4H-benzo[h]chromen-4-one
EINECS	Contact for details

Quality Control

Our α-Naphthoflavone-7,8-Dihydrodiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing results from HPLC, NMR, and MS analysis. Our quality commitment ensures the material is suitable for demanding applications as a research-grade biochemical and reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.