Description

n-Octadecanoyl-L-Valine Sodium Salt is a synthetic, sodium salt derivative of L-valine acylated with stearic acid (n-octadecanoic acid), widely employed as a high-purity surfactant and chiral building block in advanced pharmaceutical and cosmetic formulations. Its amphiphilic structure confers excellent emulsifying, solubilizing, and membrane-permeability-enhancing properties—critical for drug delivery systems and peptide-based therapeutics. This compound is essential for R&D and manufacturing teams in biopharmaceutical development, transdermal formulation design, and specialty cosmetic actives synthesis.

Application

• Chiral auxiliary and intermediate in the synthesis of protease inhibitors and antiviral peptides
• Stabilizing agent and permeation enhancer in liposomal and nanoemulsion-based drug delivery systems
• Biocompatible surfactant in high-end dermocosmetic formulations (e.g., anti-aging serums, barrier-repair creams)
• Matrix component in MALDI-TOF mass spectrometry for improved ionization of hydrophobic peptides
• Functional excipient in oral solid dosage forms requiring enhanced dissolution of poorly water-soluble APIs
• Surface-modifying ligand for gold and iron oxide nanoparticles in diagnostic nanocarriers

Basic Information

Product Name	n-Octadecanoyl-L-Valine Sodium Salt
CAS No.	85902-09-6
Molecular Formula	C21H38NO3Na
Molecular Weight	375.53 g/mol
Synonyms	Sodium N-stearoyl-L-valinate; Sodium N-(octadecanoyl)-L-valinate; Sodium N-stearoylvalinate; Stearoyl-L-valine sodium salt; Sodium (2S)-2-[(octadecanoyl)amino]-3-methylbutanoate; Sodium N-(1-oxooctadecyl)-L-valinate; C18-L-Valine Na salt; Sodium N-stearoyl-L-α-aminobutyrate (misnomer, included for search coverage)
EINECS	Not listed (no EINECS registration found; subject to REACH pre-registration inquiry)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (FT-IR, NMR), assay (HPLC), residual solvents (GC), heavy metals (ICP-MS), and microbiological limits per USP & EP guidelines. The material meets ISO 9001:2015 and cGMP-compliant manufacturing requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccated storage conditions or nitrogen-purged packaging for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Odor	Faint, characteristic
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.5%
Residue on Ignition	≤ 0.2%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%
pH (1% aqueous solution)	6.8 – 7.4

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.