Description

A-Methylbenzylzinc Bromide is a versatile organozinc reagent, specifically a benzylic zinc bromide, widely used in modern organic synthesis. Its primary value lies in enabling efficient carbon-carbon bond formation, particularly in stereoselective reactions, which is critical for constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity, reactive intermediates for cross-coupling and nucleophilic addition reactions.

Application

• Key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Precursor for the production of chiral ligands and catalysts used in asymmetric synthesis.
• Building block for advanced materials, including liquid crystals and specialty polymers.
• Reagent for Negishi cross-coupling reactions to form biaryl and alkyl-aryl compounds.
• Nucleophilic source for 1,2-addition reactions to carbonyl compounds (aldehydes, ketones).
• Used in academic and industrial R&D for methodological development in organometallic chemistry.

Basic Information

Product Name	A-Methylbenzylzinc Bromide
CAS No.	85459-20-7
Molecular Formula	C8H9BrZn
Molecular Weight	250.45 g/mol
Synonyms	(1-Phenylethyl)zinc bromide; α-Methylbenzylzinc bromide; 1-Phenylethylzinc bromide; (RS)-1-Phenylethylzinc bromide; Zinc, bromo(1-phenylethyl)-; Bromo(1-phenylethyl)zinc; rac-1-Phenylethylzinc bromide
EINECS	Contact for details

Quality Control

Our A-Methylbenzylzinc Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analysis, including titration for active zinc content and spectroscopic identification. A Certificate of Analysis (COA) detailing purity, concentration (typically supplied as a solution in tetrahydrofuran or diethyl ether), and impurity profile is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition. For optimal stability, store the sealed container at 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Concentration	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95% (as organozinc species)
Solvent Content (GC)	Balance

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.