Description

(R)-2-Chloro-3-Methylbutyric Acid CAS NO 84918-96-7 is a high-purity chiral building block essential for the synthesis of optically active pharmaceuticals and agrochemicals. Its value lies in the defined stereochemistry of the (R)-enantiomer, which is critical for imparting specific biological activity and efficacy in final active ingredients. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new drugs, crop protection agents, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for cardiovascular, antiviral, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and insecticides where stereochemistry affects potency and environmental safety.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or catalysts used in enantioselective synthesis.
• Fine Chemical Building Block: Employed in academic and industrial R&D for constructing complex organic molecules with defined stereocenters.
• Peptide Mimetics: Useful in the development of peptidomimetics and modified amino acids for drug discovery.

Basic Information

Product Name	(R)-2-Chloro-3-Methylbutyric Acid
CAS No.	84918-96-7
Molecular Formula	C5H9ClO2
Molecular Weight	136.58 g/mol
Synonyms	(R)-2-Chloro-3-methylbutanoic acid; (R)-2-Chloro-3-methylbutyric acid; (2R)-2-Chloro-3-methylbutanoic acid; (+)-(R)-2-Chloro-3-methylbutyric acid; D-2-Chloro-3-methylbutyric acid; (R)-2-Chloro-β-methylbutyric acid; 84918-96-7; Butanoic acid, 2-chloro-3-methyl-, (2R)-
EINECS	Contact for details

Quality Control

Our (R)-2-Chloro-3-Methylbutyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, GC, and NMR, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.