Description

1-(4-Bromophenyl)-2,2,2-Trifluoroethyl Trifluoromethanesulfonate is a high-value, multi-functional organofluorine building block and triflate ester. Its structure, featuring both a bromoaryl group and a reactive trifluoromethanesulfonate (triflate) leaving group, makes it a critical intermediate for constructing complex molecules in advanced chemical synthesis. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for introducing fluorinated motifs and facilitating key coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the 4-bromophenyl and trifluoroethyl pharmacophores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where fluorinated compounds enhance biological activity and environmental stability.
• Cross-Coupling Reactions: Serves as an excellent electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the reactive triflate group.
• Material Science Research: Employed in the creation of specialty monomers and polymers, including liquid crystals and organic electronic materials.
• Fluorination Chemistry: Acts as a versatile scaffold for further fluorination or functional group transformations in medicinal chemistry programs.
• Laboratory Reagent: Used in academic and industrial research settings for method development and exploring new synthetic pathways involving fluorinated compounds.

Basic Information

Product Name	1-(4-Bromophenyl)-2,2,2-Trifluoroethyl Trifluoromethanesulfonate
CAS No.	84877-48-5
Molecular Formula	C9H5BrF6O3S
Molecular Weight	387.10 g/mol
Synonyms	1-(4-Bromophenyl)-2,2,2-trifluoroethyl trifluoromethanesulfonate; 1-(4-Bromophenyl)-2,2,2-trifluoroethyl triflate; 4-Bromo-α,α,α-trifluoroacetophenone triflate; (4-Bromophenyl)(trifluoromethyl)methyl trifluoromethanesulfonate; Trifluoromethanesulfonic acid 1-(4-bromophenyl)-2,2,2-trifluoroethyl ester; p-Bromobenzotrifluoride triflate derivative; BTF Triflate
EINECS	Contact for details

Quality Control

Our production of 1-(4-Bromophenyl)-2,2,2-Trifluoroethyl Trifluoromethanesulfonate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP manufacturing requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.