Description

1-Propanamine, n-(2-Chloroethyl)-n-Methyl-3-(Triethylsilyl)-, Hydrochloride is a specialized organosilicon amine derivative, valued for its unique molecular structure that combines a reactive chloroethyl group with a silyl-protected amine. This compound is engineered to serve as a critical synthetic intermediate, enabling the controlled introduction of functionalized amine and silicon moieties into complex molecular architectures. It is primarily sought by research and development chemists in the pharmaceutical and advanced materials sectors for applications in drug discovery, peptide synthesis, and the development of novel silicon-containing polymers and surface modifiers.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological or oncological pathways where the chloroethyl group can be utilized for alkylation or further functionalization.
• Peptide Modification Reagent: Used to introduce silyl-protected amine functionalities into peptide chains, aiding in the study of structure-activity relationships and the development of peptide-based therapeutics.
• Advanced Material Synthesis: Serves as a precursor in the creation of silicon-based polymers, dendrimers, and hybrid organic-inorganic materials with tailored surface properties.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for asymmetric catalysis or as a component in organometallic catalyst systems.
• Surface Functionalization Agent: Used to modify the surface chemistry of silica, glass, or other substrates to impart specific amine-reactive sites for further coupling.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on exploring new synthetic methodologies involving organosilicon chemistry.

Basic Information

Product Name	1-Propanamine, n-(2-Chloroethyl)-n-Methyl-3-(Triethylsilyl)-, Hydrochloride
CAS No.	84584-74-7
Molecular Formula	C12H29Cl2NSi
Molecular Weight	310.36 g/mol
Synonyms	N-(2-Chloroethyl)-N-methyl-3-(triethylsilyl)propan-1-amine hydrochloride; 3-(Triethylsilyl)-N-(2-chloroethyl)-N-methylpropan-1-amine hydrochloride; N-Methyl-N-(2-chloroethyl)-3-(triethylsilyl)-1-propanamine hydrochloride; (3-((2-Chloroethyl)(methyl)amino)propyl)triethylsilane hydrochloride; Triethyl[3-[(2-chloroethyl)methylamino]propyl]silane hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 1-Propanamine, n-(2-Chloroethyl)-n-Methyl-3-(Triethylsilyl)-, Hydrochloride is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support cGMP-compliant production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.