Description

Rocaglamide CAS NO 84573-16-0 is a potent natural product belonging to the class of flavaglines, originally isolated from plants of the genus *Aglaia*. This compound matters significantly due to its powerful and selective anti-cancer properties, primarily through the inhibition of eukaryotic translation initiation factor 4A (eIF4A). Researchers and pharmaceutical developers need it as a critical reference standard and a promising lead compound for oncology research, drug discovery, and the development of novel therapeutic agents targeting protein synthesis in cancer cells.

Application

• Oncology Research & Drug Discovery: Serves as a key pharmacological tool and lead compound for studying eIF4A inhibition and developing novel anti-cancer therapies.
• Biochemical & Cell Biology Studies: Used to investigate mechanisms of protein translation, apoptosis induction, and cell cycle arrest in various cancer cell lines.
• Reference Standard for Analytical Testing: Essential for HPLC, LC-MS, or NMR method development and validation in quality control laboratories for related products.
• Pharmaceutical Intermediate: Employed in the synthesis and development of more potent or selective flavagline derivatives and analogs.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies on natural product chemistry and cancer biology.

Basic Information

Product Name	Rocaglamide
CAS No.	84573-16-0
Molecular Formula	C₂₉H₃₁NO₇
Molecular Weight	505.56 g/mol
Synonyms	Roc-A; (-)-Rocaglamide; Rocaglamide A; 1H-Cyclopenta[b]benzofuran-4-methanol, 8-(1,3-benzodioxol-5-yl)-1,2,6,7,8,8a-hexahydro-6,6-dimethyl-1-oxo-α-(phenylmethyl)-, (1R,2R,3aS,8aR)-rel-; NSC 367251; Flavagline Rocaglamide; Aglaiastatin
EINECS	Contact for details

Quality Control

Our Rocaglamide is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We support our clients with the documentation required for regulatory and institutional submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.