Description

Mono-2-o-(p-Toluenesulfonyl)-β-Cyclodextrin is a key functionalized derivative of β-cyclodextrin, specifically modified with a single tosyl group at the 2-O position of the glucose ring. This targeted modification is critical for creating advanced pharmaceutical intermediates and novel host-guest complexes with tailored solubility and binding properties. It serves as a vital building block for researchers and manufacturers in pharmaceutical development, analytical chemistry, and advanced material science, enabling the synthesis of more sophisticated drug delivery systems and separation media.

Application

• Pharmaceutical Intermediate: Acts as a key precursor for synthesizing more complex, site-specifically modified cyclodextrin derivatives used in drug formulation and delivery.
• Chiral Stationary Phase Synthesis: Used to create selective media for High-Performance Liquid Chromatography (HPLC) and capillary electrophoresis to separate enantiomers.
• Molecular Encapsulation Agent: Facilitates the study and enhancement of solubility, stability, and bioavailability of poorly soluble active pharmaceutical ingredients (APIs).
• Polymer & Material Science: Serves as a monofunctional initiator or modifier for creating cyclodextrin-based polymers, hydrogels, and smart materials.
• Catalyst & Ligand Design: Provides a structured scaffold for anchoring catalytic sites or creating enzyme mimics in supramolecular chemistry.
• Analytical Reference Standard: Employed as a high-purity standard for method development and quality control in analytical laboratories.

Basic Information

Product Name	Mono-2-o-(p-Toluenesulfonyl)-β-Cyclodextrin
CAS No.	84216-71-7
Molecular Formula	C55H84O41S
Molecular Weight	1329.29 g/mol
Synonyms	2-O-(p-Tolylsulfonyl)-β-cyclodextrin; 2-O-Tosyl-β-cyclodextrin; β-Cyclodextrin 2-O-monotosylate; Mono(2-O-tosyl)-β-cyclodextrin; 6^A-Deoxy-6^A-[(4-methylphenyl)sulfonyl]-β-cyclodextrin; Heptakis[6-deoxy-6-[(4-methylphenyl)sulfonyl]]-β-cyclodextrin (incorrect for mono, listed for search); Ts-β-CD (common abbreviation)
EINECS	Contact for details

Quality Control

Our Mono-2-o-(p-Toluenesulfonyl)-β-Cyclodextrin is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and structural confirmation by NMR and MS, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.