Description

cis-3-Benzyloxycyclobutanecarboxylic Acid is a versatile chiral cyclobutane derivative, a high-value building block in advanced organic synthesis. Its unique structure, featuring a carboxylic acid group and a benzyl-protected hydroxyl moiety on a strained cyclobutane ring, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and antiviral drug research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging its rigid cyclobutane core for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers and polymers with specific stereochemical and physical properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study enzyme function and biological pathways.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including ring-opening and functionalization reactions.

Basic Information

Item	Details
Product Name	cis-3-Benzyloxycyclobutanecarboxylic Acid
CAS No.	84182-47-8
Molecular Formula	C12H14O3
Molecular Weight	206.24 g/mol
Synonyms	(1r,3s)-3-(Benzyloxy)cyclobutanecarboxylic Acid; (1R,3S)-3-(Phenylmethoxy)cyclobutanecarboxylic Acid; cis-3-(Benzyloxy)cyclobutanecarboxylic Acid; (1R,3S)-3-Benzyloxycyclobutanecarboxylic Acid; 3-Benzyloxycyclobutanecarboxylic Acid, cis-; Cyclobutanecarboxylic acid, 3-(phenylmethoxy)-, (1R,3S)-rel-; rel-(1R,3S)-3-(Benzyloxy)cyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our cis-3-Benzyloxycyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and isomeric purity suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.