Description

1-(3,4-Dihydro-2H-1-Benzopyran-3-Yl)-4-(4-Fluorophenyl)Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure combining a chroman and a piperazine moiety. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop new therapeutic agents with potential antipsychotic or neuroprotective properties, ensuring process efficiency and final product quality.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel central nervous system (CNS) active drugs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex molecules targeting specific neurological receptors.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Preclinical & Clinical Trial Material Production: Supplied under controlled conditions for the manufacture of compounds used in non-clinical and clinical studies.
• Contract Development and Manufacturing Organization (CDMO) Services: A critical raw material for custom synthesis and scale-up projects.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	1-(3,4-Dihydro-2H-1-Benzopyran-3-Yl)-4-(4-Fluorophenyl)Piperazine
CAS No.	83823-55-6
Molecular Formula	C19H21FN2O
Molecular Weight	312.38 g/mol
Synonyms	4-(4-Fluorophenyl)-1-(3,4-dihydro-2H-chromen-3-yl)piperazine; 1-(Chroman-3-yl)-4-(4-fluorophenyl)piperazine; 83823-55-6; 4-(4-Fluorophenyl)-1-(3,4-dihydro-2H-1-benzopyran-3-yl)piperazine; 3-[4-(4-Fluorophenyl)piperazin-1-yl]chroman; 1-(3,4-Dihydro-2H-chromen-3-yl)-4-(4-fluorophenyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-(3,4-Dihydro-2H-1-Benzopyran-3-Yl)-4-(4-Fluorophenyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent in-house specifications suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.