Description

2-(Bromomethyl)-1-Chloro-3-Methoxybenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its dual reactive sites, the bromomethyl and chloro substituents, which allow for sequential and selective functionalization. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing substituted benzyl or phenethylamine motifs.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the methoxy-chloro-benzyl structure is a core component.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized phosphine or nitrogen-based ligands used in catalysis.
• Material Science Research: Employed in the creation of novel monomers or functionalized polymers with specific electronic or structural properties.
• Cross-Coupling Reactions: The bromomethyl group is an effective electrophile for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Substitution Scaffold: The chloro and bromo groups offer orthogonal reactivity for stepwise nucleophilic substitutions to create diverse chemical libraries.

Basic Information

Product Name	2-(Bromomethyl)-1-Chloro-3-Methoxybenzene
CAS No.	83781-95-7
Molecular Formula	C8H8BrClO
Molecular Weight	235.51 g/mol
Synonyms	1-Chloro-2-(bromomethyl)-3-methoxybenzene; 3-Chloro-2-methoxybenzyl bromide; 2-Methoxy-6-chlorobenzyl bromide; (3-Chloro-2-methoxyphenyl)methyl bromide; 2-Chloro-6-methoxybenzyl bromide; 83781-95-7; 1-Chloro-3-methoxy-2-(bromomethyl)benzene
EINECS	Contact for details

Quality Control

Every batch of our 2-(Bromomethyl)-1-Chloro-3-Methoxybenzene is produced and tested under a strict quality management system. We ensure high purity and consistency to meet the exacting standards required for research and scale-up processes. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee traceability and batch-to-batch reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.