Description

Toluene-4-Sulfonic Acid (S)-1-Chlorocarbonyl-Ethyl Ester is a high-purity chiral building block and activated ester derivative of p-toluenesulfonic acid. This compound matters for its role as a key intermediate in the stereoselective synthesis of complex molecules, particularly in pharmaceutical development. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for constructing active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides requiring specific stereochemistry for efficacy.
• Peptide Chemistry: Serves as an activated ester for coupling reactions in peptide synthesis and modification.
• Asymmetric Catalysis Research: Employed as a precursor or reagent in the development of new chiral catalysts and ligands.
• Material Science: Utilized in the synthesis of specialty polymers and advanced organic materials with tailored properties.
• Custom Synthesis & Contract Manufacturing: A valuable building block for custom chemical synthesis services targeting niche applications.

Basic Information

Product Name	Toluene-4-Sulfonic Acid (S)-1-Chlorocarbonyl-Ethyl Ester
CAS No.	83261-13-6
Molecular Formula	C10H11ClO4S
Molecular Weight	262.71 g/mol
Synonyms	(S)-(-)-1-Chloroethyl p-Toluenesulfonate; (S)-1-Chloroethyl Tosylate; (S)-1-Chloroethyl 4-Methylbenzenesulfonate; (S)-α-Chloroethyl p-Toluenesulfonate; p-Toluenesulfonic Acid (S)-1-Chlorocarbonylethyl Ester; (S)-CET; Tosyl (S)-1-Chloroethyl Ester; (S)-1-Chloroethyl Tosylate Ester
EINECS	Contact for details

Quality Control

Our Toluene-4-Sulfonic Acid (S)-1-Chlorocarbonyl-Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with high-grade standards suitable for research and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.