Description

(Diethoxyphosphoryl)Difluoromethylzinc Bromide is a highly reactive organozinc reagent, specifically a Reformatsky-type reagent, used for the efficient introduction of the difluoromethylphosphonate moiety. This compound matters because it enables the synthesis of complex, fluorinated molecules, which are critical for modulating the biological activity and physicochemical properties of target compounds. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in creating advanced, fluorinated pesticides and herbicides with enhanced efficacy and environmental profile.
• Material Science Research: Employed in the development of fluorinated organic materials and ligands for catalysis.
• Cross-Coupling Reactions: Acts as a nucleophilic reagent in Negishi and related cross-coupling reactions to form carbon-carbon bonds.
• Fluorine Chemistry: Essential reagent for the study and incorporation of difluoromethylphosphonate groups, which are bioisosteres for phosphate and carboxylate groups.
• Process Chemistry: Utilized in scale-up and optimization of routes to fluorinated target molecules in pilot plants.

Basic Information

Product Name	(Diethoxyphosphoryl)Difluoromethylzinc Bromide
CAS No.	82845-20-3
Molecular Formula	C5H10BrF2O2PZn
Molecular Weight	306.40 g/mol
Synonyms	Bromo(diethoxyphosphoryl)difluoromethylzinc; Zinc, bromo[2-(diethoxyphosphinyl)-1,1-difluoroethyl]-; Difluoromethylphosphonic Acid Diethyl Ester Zinc Bromide Adduct; (Diethoxyphosphoryl)difluoromethyl Zinc Bromide; Reformatsky Reagent, (Diethoxyphosphoryl)difluoromethyl-; 1,1-Difluoro-2-(diethoxyphosphinyl)ethylzinc Bromide; (Diethyl Phosphonodifluoroacetate)Zinc Bromide
EINECS	Contact for details

Quality Control

Our (Diethoxyphosphoryl)Difluoromethylzinc Bromide is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including NMR, titration for active zinc content, and impurity profiling, to ensure consistency and high reactivity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and solvent content. Our quality system is designed to support cGMP requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For extended stability, storage at 2-8°C is recommended. The container should be kept in a well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution (typically in THF)
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (Zinc content)	≥ 95%
Water Content (KF)	< 500 ppm
Solvent (THF)	Balance

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.