Description

(S)-(-)-n-[1-(Hydroxymethyl)-2-Phenylethyl]-4-Methylbenzenesulfonamide is a high-purity chiral sulfonamide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a defined stereochemical center essential for creating enantiomerically pure compounds, which is paramount for efficacy and safety in pharmaceutical development. This intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of enantiomerically pure drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Employed as a chiral auxiliary or resolving agent in stereoselective chemical reactions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Chemistry Development: Serves as a standard or reference material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and receptor binding.
• Academic Research: A valuable compound for teaching and investigating principles of stereochemistry and sulfonamide chemistry.

Basic Information

Product Name	(S)-(-)-n-[1-(Hydroxymethyl)-2-Phenylethyl]-4-Methylbenzenesulfonamide
CAS No.	82495-70-3
Molecular Formula	C₁₇H₂₁NO₃S
Molecular Weight	319.42 g/mol
Synonyms	(S)-N-[1-(Hydroxymethyl)-2-phenylethyl]-4-methylbenzenesulfonamide; (S)-(-)-Tosylamide Derivative; (S)-N-(1-Hydroxymethyl-2-phenylethyl)-p-toluenesulfonamide; (S)-Phenylalanine Tosylamide Alcohol; (S)-2-Amino-3-phenyl-1-propanol Tosyl Derivative; L-Phenylalaninol Tosylate; (S)-HMPE-Ts; Chiral Sulfonamide Intermediate
EINECS	Contact for details

Quality Control

Our (S)-(-)-n-[1-(Hydroxymethyl)-2-Phenylethyl]-4-Methylbenzenesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.