Description

Methyl [2S-[2Alpha,3Alpha,4Beta(S*)]]-Tetrahydro-2-Methyl-6-Oxo-4-[(1-Phenylethyl)Amino]-2H-Pyran-3-Carboxylate Hydrochloride is a high-purity, complex chiral intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a critical building block in the development of novel pharmaceutical actives, particularly those targeting complex biological pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of new chemical entities (NCEs), process development, and the production of high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and anti-infective applications.
• Asymmetric Synthesis: Utilized in stereoselective synthesis to construct complex molecular architectures with defined three-dimensional configurations.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate in the optimization and pilot-scale production of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new bioactive molecules.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.

Basic Information

Item	Details
Product Name	Methyl [2S-[2Alpha,3Alpha,4Beta(S*)]]-Tetrahydro-2-Methyl-6-Oxo-4-[(1-Phenylethyl)Amino]-2H-Pyran-3-Carboxylate Hydrochloride
CAS No.	81972-25-0
Molecular Formula	C16H22ClNO4
Molecular Weight	327.80 g/mol
Synonyms	Methyl (2S,3S,4R)-2-methyl-6-oxo-4-[(1S)-1-phenylethyl]amino]tetrahydro-2H-pyran-3-carboxylate hydrochloride; (2S,3S,4R)-Methyl 2-methyl-6-oxo-4-[(1S)-1-phenylethylamino]tetrahydro-2H-pyran-3-carboxylate hydrochloride; Tetrahydro-2-methyl-6-oxo-4-[(1-phenylethyl)amino]-2H-pyran-3-carboxylic acid methyl ester hydrochloride; A chiral dihydropyranone derivative hydrochloride salt; (3S,4R)-Methyl 4-((S)-1-phenylethylamino)-2-methyl-6-oxotetrahydro-2H-pyran-3-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.