Description

Benzyl 2,2,2-Trichloroacetimidate is a versatile and highly reactive chemical intermediate, primarily utilized as a key reagent in organic synthesis. Its core value lies in its ability to function as a powerful glycosyl donor, enabling the efficient and stereoselective construction of glycosidic bonds, which are fundamental to carbohydrate chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly those developing active pharmaceutical ingredients (APIs), complex natural products, and novel materials.

Application

• Glycosylation Reactions: Serves as a critical reagent for the stereoselective synthesis of O-glycosides, a fundamental step in carbohydrate and glycoconjugate chemistry.
• Pharmaceutical Intermediate: Used in the research and production of complex drug molecules, especially antibiotics, antivirals, and anticancer agents containing sugar moieties.
• Natural Product Synthesis: Enables the construction of oligosaccharide chains found in natural products, facilitating studies in biochemistry and drug discovery.
• Agrochemical Development: Applied in the synthesis of novel glycosylated pesticides or plant growth regulators.
• Fine Chemical Synthesis: Acts as a building block for creating specialized surfactants, detergents, or other functional materials with specific carbohydrate-based properties.
• Bioconjugation: Potential use in linking carbohydrate epitopes to proteins or other biomolecules for vaccine development and diagnostic applications.

Basic Information

Product Name	Benzyl 2,2,2-Trichloroacetimidate
CAS No.	81927-55-1
Molecular Formula	C9H8Cl3NO
Molecular Weight	252.52 g/mol
Synonyms	Benzyl Trichloroacetimidate; 2,2,2-Trichloro-N-(phenylmethoxy)ethanimidoyl Chloride (common misnomer); Benzyl O-(Trichloroacetimidoyl) Ether; (Benzyloxy)(trichloromethyl)carbene Imine; Glycosyl Donor Reagent; Trichloroacetimidic Acid Benzyl Ester; BnOC(=NH)CCl3
EINECS	Contact for details

Quality Control

Our Benzyl 2,2,2-Trichloroacetimidate is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and GC. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.