Description

2-Chloro-5-Fluorobenzyl Bromide is a versatile and highly reactive halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the aromatic ring, makes it an essential intermediate for introducing specific functional groups and modifying molecular properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of novel small-molecule drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the halogenated benzyl group imparts specific biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing specialized fluorinated organic compounds used in electronic displays.
• Cross-Coupling Reactions: An effective electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Functional Group Introduction: Utilized to introduce the benzyl bromide moiety into target molecules for further functionalization or as a protecting group strategy.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries.

Basic Information

Product Name	2-Chloro-5-Fluorobenzyl Bromide
CAS No.	81778-09-8
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-(Bromomethyl)-2-chloro-5-fluorobenzene; (2-Chloro-5-fluorophenyl)methyl bromide; α-Bromo-2-chloro-5-fluorotoluene; 2-Chloro-5-fluorobenzyl bromide; 2-Chloro-5-fluorobenzylbromide; 2-Chloro-5-fluoro-benzylbromide; 2-Chloro-5-fluorobenzyl bromide, 97%; 2-Chloro-5-fluorobenzyl bromide, 95%
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluorobenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and light-sensitive nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.