Description

Boc-Glu(Osu)-Otbu is a protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is essential for introducing glutamic acid residues with orthogonal protecting groups, enabling complex peptide chain assembly. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for developing novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A crucial reagent for the controlled incorporation of glutamic acid into peptide sequences.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing specific peptide fragments.
• Pharmaceutical Intermediate: Serves as a key raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Facilitates the chemical modification of proteins, antibodies, or other biomolecules for drug delivery and diagnostic applications.
• Biochemical Research: Employed in academic and industrial labs for studying enzyme-substrate interactions and protein structure-function relationships.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive peptide leads.

Basic Information

Product Name	Boc-Glu(Osu)-Otbu
CAS No.	81659-82-7
Molecular Formula	C19H30N2O9
Molecular Weight	430.45 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-L-glutamic acid 1-(2,5-dioxopyrrolidin-1-yl) ester 5-tert-butyl ester; N-Boc-L-glutamic acid α-N-hydroxysuccinimide ester γ-t-butyl ester; Boc-Glu(OSu)-OtBu; Boc-L-Glu(OSu)-OtBu; (2S)-2-[(tert-Butoxycarbonyl)amino]-5-(tert-butoxy)-5-oxopentanoic acid 2,5-dioxopyrrolidin-1-yl ester; Boc-Glu(ONSu)-OtBu; tert-Butyl N-[(1S)-4-(tert-butoxy)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1,4-dioxobutan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Boc-Glu(Osu)-Otbu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.