Description

1-(3,5-Bis-Trimethylsilanyl-Phenyl)-Ethanone is a specialized organosilicon compound featuring a protected aromatic ketone functionality, making it a valuable intermediate in advanced synthetic chemistry. Its core value lies in its role as a key building block for the synthesis of complex molecules, particularly in pharmaceutical research and materials science. This product is essential for R&D chemists and process development scientists working in pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, functionalized intermediates for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring silyl-protected aromatic systems.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the trimethylsilyl groups offer strategic synthetic advantages.
• Ligand & Catalyst Development: Serves as a starting material for creating sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and other advanced materials due to its modified electronic properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, such as Suzuki or Heck reactions, where the protected ketone group is crucial for subsequent transformations.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on new synthetic methodologies and compound library generation.

Basic Information

Product Name	1-(3,5-Bis-Trimethylsilanyl-Phenyl)-Ethanone
CAS No.	81500-98-3
Molecular Formula	C14H24OSi2
Molecular Weight	264.51 g/mol
Synonyms	1-[3,5-Bis(trimethylsilyl)phenyl]ethanone; 3',5'-Bis(trimethylsilyl)acetophenone; Ethanone, 1-[3,5-bis(trimethylsilyl)phenyl]-; Acetophenone, 3',5'-bis(trimethylsilyl)-; 3,5-Bis(trimethylsilyl)acetophenone; TMS-Protected Acetophenone Derivative; CAS 81500-98-3
EINECS	Contact for details

Quality Control

Our 1-(3,5-Bis-Trimethylsilanyl-Phenyl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.