Description

Dimethylisopropylsilylimidazole is a specialized organosilicon reagent primarily used as a versatile silylating agent. This compound is critical for introducing the dimethylisopropylsilyl (DMIPS) protecting group, offering a valuable balance of stability and reactivity for advanced synthetic chemistry. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require precise protection of sensitive functional groups.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the protection of hydroxyl groups in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Nucleoside & Carbohydrate Chemistry: Used to selectively silylate sugar hydroxyls in the production of modified nucleosides, nucleotides, and complex carbohydrates.
• Agrochemical Development: Employed in the synthesis of advanced pesticide and herbicide intermediates where selective protection is required.
• Peptide & Steroid Modification: Facilitates the temporary protection of reactive sites during the synthesis and modification of peptides and steroid derivatives.
• Material Science Research: Serves as a precursor or modifying agent in the development of specialty silicones and silicon-based polymers.
• Process Chemistry & Scale-up: Valued for its consistent performance and purity in pilot plant and commercial-scale manufacturing processes.

Basic Information

Product Name	Dimethylisopropylsilylimidazole
CAS No.	81452-04-2
Molecular Formula	C8H18N2Si
Molecular Weight	170.33 g/mol
Synonyms	1-(Dimethylisopropylsilyl)imidazole; DMIPS-Imidazole; Dimethyl(isopropyl)silyl imidazole; N-(Dimethylisopropylsilyl)imidazole; Imidazole, 1-[(1,1-dimethylethyl)dimethylsilyl]-; tert-Butyldimethylsilyl imidazole analog (isopropyl); Isopropyldimethylsilyl imidazole
EINECS	Contact for details

Quality Control

Our Dimethylisopropylsilylimidazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for use in regulated synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.