Description

1-Phenyl-4-Trimethylsilyl-1-Butanol is a versatile organosilicon compound featuring both a phenyl and a trimethylsilyl-protected alcohol functional group. This unique structure makes it a valuable intermediate and building block in advanced organic synthesis, particularly for the pharmaceutical and agrochemical industries. It is primarily sought after by R&D chemists and process development scientists for constructing complex molecules where precise control over stereochemistry and functional group protection is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting the central nervous system.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging its silicon moiety for enhanced biological activity or stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as hydrogenation or cross-coupling reactions.
• Material Science Research: Employed in the development of novel silicon-containing polymers and advanced organic materials.
• Fine Chemical Production: Acts as a building block for specialty chemicals, flavors, and fragrances requiring specific structural motifs.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis and new reaction development.

Basic Information

Product Name	1-Phenyl-4-Trimethylsilyl-1-Butanol
CAS No.	80496-45-3
Molecular Formula	C₁₃H₂₂OSi
Molecular Weight	222.40 g/mol
Synonyms	4-(Trimethylsilyl)-1-phenyl-1-butanol; 1-Phenyl-4-(trimethylsilyl)butan-1-ol; 1-Butanol, 1-phenyl-4-(trimethylsilyl)-; 1-Phenyl-4-trimethylsilylbutan-1-ol; γ-(Trimethylsilyl)-γ-phenylpropanol; (4-Hydroxy-4-phenylbutyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our 1-Phenyl-4-Trimethylsilyl-1-Butanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.