Description

Sta 2 CAS NO 80408-46-4 is a high-purity chemical intermediate, also known as a statin side chain precursor, valued for its critical role in the synthesis of advanced pharmaceutical compounds. Its importance lies in providing a reliable and consistent building block for creating active pharmaceutical ingredients (APIs) that require specific stereochemistry and functional groups. This product is essential for manufacturers in the pharmaceutical and fine chemical industries engaged in the research, development, and production of cholesterol-lowering drugs and other complex therapeutic agents.

Application

• Pharmaceutical Synthesis: A key chiral intermediate in the production of statin-class drugs, such as Atorvastatin and Rosuvastatin.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a crucial building block for constructing the complex side chain of HMG-CoA reductase inhibitors.
• Fine Chemical Production: Used in the synthesis of other high-value, optically active compounds for research and development.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for commercial drug production.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and pharmaceutical development services.
• Academic & Industrial Research: Utilized in medicinal chemistry programs for the discovery of new therapeutic entities targeting metabolic pathways.

Basic Information

Product Name	Sta 2
CAS No.	80408-46-4
Molecular Formula	C19H19F2NO4
Molecular Weight	363.36 g/mol
Synonyms	(3R,5S)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic Acid; (3R,5S)-Atorvastatin Lactone; Atorvastatin Lactone Intermediate; Statin Side Chain Lactone; (4R,6S)-6-[(1E)-2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylamino)carbonyl-1H-pyrrol-1-yl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; STA-2; CAS 80408-46-4.
EINECS	Contact for details

Quality Control

Our Sta 2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity analysis, to meet the stringent requirements of pharmaceutical applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.