Description

(S)-1,4,7,10,13,16-Hexaoxacyclooctadecane-2-Methanol is a chiral crown ether derivative, specifically the (S)-enantiomer of 18-crown-6 tetracarboxylic acid, valued for its exceptional enantioselective binding properties. This compound is critical for applications requiring high-purity chiral separation and phase-transfer catalysis. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for asymmetric synthesis and analytical method development.

Application

• Chiral Phase-Transfer Catalyst: Employed in asymmetric synthesis to produce enantiomerically pure pharmaceutical intermediates and fine chemicals.
• Enantioselective Separation Agent: Used as a chiral selector in capillary electrophoresis (CE), high-performance liquid chromatography (HPLC), and other analytical techniques.
• Molecular Recognition Studies: Serves as a key ligand in host-guest chemistry research for studying chiral discrimination mechanisms.
• Asymmetric Polymerization Initiator: Facilitates the production of optically active polymers with specific helical structures.
• Sensor Development: Incorporated into chiral sensor platforms for the detection and quantification of specific enantiomers.
• Chemical Synthesis Intermediate: Used as a building block for synthesizing more complex, functionalized crown ether derivatives.

Basic Information

Product Name	(S)-1,4,7,10,13,16-Hexaoxacyclooctadecane-2-Methanol
CAS No.	80004-04-2
Molecular Formula	C14H26O8
Molecular Weight	322.35 g/mol
Synonyms	(S)-18-Crown-6 Tetracarboxylic Acid; (S)-2-(Hydroxymethyl)-18-crown-6; (S)-1,4,7,10,13,16-Hexaoxacyclooctadecane-2-methanol; (S)-HEC; (S)-2-Hydroxymethyl-1,4,7,10,13,16-hexaoxacyclooctadecane; (S)-2-(Hydroxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane; (S)-Chiral 18-Crown-6 Ether Derivative
EINECS	Contact for details

Quality Control

Our (S)-1,4,7,10,13,16-Hexaoxacyclooctadecane-2-Methanol is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including chiral HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.