Description

4-Hydroxymethyl-Bicyclo[2.2.2]Octane-1-Carboxylic Acid is a highly functionalized, rigid bicyclic organic compound that serves as a valuable advanced pharmaceutical intermediate and specialty chemical building block. Its unique three-dimensional structure, featuring both a carboxylic acid and a hydroxymethyl group on a rigid bicyclo[2.2.2]octane scaffold, makes it a critical synthon for designing molecules with specific spatial and electronic properties. This compound is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those requiring rigid, three-dimensional frameworks to enhance binding affinity and metabolic stability.
• Ligand and Catalyst Development: Used to create novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for producing specialty polymers with enhanced thermal and mechanical properties.
• Material Science Research: Employed in the development of advanced organic materials, such as metal-organic frameworks (MOFs) or molecular cages.
• Agrochemical Synthesis: Intermediate for creating novel crop protection agents with unique modes of action.
• Academic & Industrial R&D: A versatile scaffold for medicinal chemistry, chemical biology, and discovery chemistry programs.

Basic Information

Product Name	4-Hydroxymethyl-Bicyclo[2.2.2]Octane-1-Carboxylic Acid
CAS No.	828-52-4
Molecular Formula	C10H16O3
Molecular Weight	184.23 g/mol
Synonyms	4-(Hydroxymethyl)bicyclo[2.2.2]octane-1-carboxylic acid; 1-Carboxy-4-hydroxymethylbicyclo[2.2.2]octane; Bicyclo[2.2.2]octane-1-carboxylic acid, 4-(hydroxymethyl)-; 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid; 1-Bicyclo[2.2.2]octanecarboxylic acid, 4-(hydroxymethyl)-; 4-Carboxybicyclo[2.2.2]octane-1-methanol
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxymethyl-Bicyclo[2.2.2]Octane-1-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.